Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/23044
DC Field | Value | |
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dc.title | Jagged-notch signaling in zebrafish pronephros development | |
dc.contributor.author | MA MING | |
dc.date.accessioned | 2011-06-10T18:00:51Z | |
dc.date.available | 2011-06-10T18:00:51Z | |
dc.date.issued | 2007-08-07 | |
dc.identifier.citation | MA MING (2007-08-07). Jagged-notch signaling in zebrafish pronephros development. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/23044 | |
dc.description.abstract | Jagged-Notch pathway genes and essential kidney developmental gene pax2a and pax8 are dynamically expressed in the different segment of the zebrafish pronephros. In the tubule and distal duct segments, Jagged2a-Notch signaling mediates multi-cilia cells and principal cells differentiation through lateral inhibition mechanism and Pax2a/Pax8 control differentiation process by regulating the jagged2a expression. In the tubule segment, Jagged1b/Jagged2a-Notch signaling and Pax2a/Pax8 form a positive feedback loop and this feedback loop is required for the maintenance of tubule. Jagged(s)-Notch signaling positively regulates pax2a expression through effector Odd-skipped related 2 (Odd2) by lateral induction mechanism. Therefore, a single ligand, Jagged2a, could do both lateral inhibition and lateral induction within a single tissue, in this case, tubule at different timing. Finally, Fgf ligands secreted from somite were found to activate tubule pax2a early in development through effecter Pea3 from 4 s to 15 s. In Fgf defective embryos tubule cells are reduced due to lower level of Pax2a-Notch feedback loop. | |
dc.language.iso | en | |
dc.subject | Kidney Pronephros Jagged Notch Pax2 Odd2 | |
dc.type | Thesis | |
dc.contributor.department | BIOCHEMISTRY | |
dc.contributor.supervisor | JIANG YUN-JIN | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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File | Description | Size | Format | Access Settings | Version | |
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Title.pdf | 37.95 kB | Adobe PDF | OPEN | None | View/Download | |
Index.pdf | 147.02 kB | Adobe PDF | OPEN | None | View/Download | |
Text.pdf | 5.52 MB | Adobe PDF | OPEN | None | View/Download |
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