Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/22641
Title: Part 1: Development and Application of Hantzsch Ester and Hypervalent Iodine Reagent Part 2: Combinatorial Synthesis of Nitrogen-Containing Heterocycles
Authors: CHE JUN
Keywords: Hantzsch ester, Iodine compound, N-containing Heterocycles
Issue Date: 13-Aug-2010
Source: CHE JUN (2010-08-13). Part 1: Development and Application of Hantzsch Ester and Hypervalent Iodine Reagent Part 2: Combinatorial Synthesis of Nitrogen-Containing Heterocycles. ScholarBank@NUS Repository.
Abstract: Since Fused 1,3-oxazin-6-ones constitute an interesting class of pharmacologically active compounds as they have shown a multitude of biological activities. Thus one of the purposes of our study is to investigate the combinatorial synthesis of N-containing heterocycles. The advantages of solid-phase reactions could be combined with the benefits of solution phase chemistry through the use of polymer-supported reagents. In addition, Hantzsch ester has been known as a good hydrogenation reagent. Thus, another purpose of our study is to investigate the development and application of the hantzsch ester. The chemistry of hypervalent iodine compounds offers multiple advantages over established methods. A wide range of reactions is possible, oxidations and C-C coupling reactions under mild reaction conditions and with a broad tolerance of other functional groups being the most prominent ones. Thus, one more purpose of our study is to investigate the development and application of the hypervalent iodine compounds.
URI: http://scholarbank.nus.edu.sg/handle/10635/22641
Appears in Collections:Ph.D Theses (Open)

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