Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.conb.2008.08.002
Title: Cortico-striatal representation of time in animals and humans
Authors: Meck, W.H.
Penney, T.B. 
Pouthas, V.
Issue Date: 2008
Source: Meck, W.H.,Penney, T.B.,Pouthas, V. (2008). Cortico-striatal representation of time in animals and humans. Current Opinion in Neurobiology 18 (2) : 145-152. ScholarBank@NUS Repository. https://doi.org/10.1016/j.conb.2008.08.002
Abstract: Interval timing in the seconds-to-minutes range is crucial to learning, memory, and decision-making. Recent findings argue for the involvement of cortico-striatal circuits that are optimized by the dopaminergic modulation of oscillatory activity and lateral connectivity at the level of cortico-striatal inputs. Striatal medium spiny neurons are proposed to detect the coincident activity of specific beat patterns of cortical oscillations, thereby permitting the discrimination of supra-second durations based upon the reoccurring patterns of subsecond neural firing. This proposal for the cortico-striatal representation of time is consistent with the observed psychophysical properties of interval timing (e.g. linear time scale and scalar variance) as well as much of the available pharmacological, lesion, patient, electrophysiological, and neuroimaging data from animals and humans (e.g. dopamine-related timing deficits in Huntington's and Parkinson's disease as well as related animal models). The conclusion is that although the striatum serves as a 'core timer', it is part of a distributed timing system involving the coordination of large-scale oscillatory networks. © 2008 Elsevier Ltd. All rights reserved.
Source Title: Current Opinion in Neurobiology
URI: http://scholarbank.nus.edu.sg/handle/10635/22250
ISSN: 09594388
DOI: 10.1016/j.conb.2008.08.002
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

226
checked on Dec 5, 2017

Page view(s)

228
checked on Dec 8, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.