Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/22126
Title: Anti-inflammatory pharmacology of histone deacetylase inhibitors in pre-clinical models of rheumatoid arthritis
Authors: CHOO QIUYI
Keywords: Inflammation, Histone, Histone Deactylase, Rheumatoid arthritis, Synovial fibroblast, NF-kappaB
Issue Date: 23-Jun-2010
Source: CHOO QIUYI (2010-06-23). Anti-inflammatory pharmacology of histone deacetylase inhibitors in pre-clinical models of rheumatoid arthritis. ScholarBank@NUS Repository.
Abstract: HDAC inhibitors have emerged as a novel class of anti-cancer agents. Their anti-rheumatic activities had been documented in various pre-clinical RA models. However, their anti-rheumatic mechanisms of action are not well elucidated. The work that was carried out for this thesis aimed to elucidate the anti-inflammatory and anti-rheumatic mechanisms of action of HDAC inhibitors. Inhibition of RASF proliferation, suppression of pro-inflammatory cytokines, chemokines and NO as well as down-regulation of angiogenesis, chemotaxis and MMPs may provide beneficial effects in RA. The aforementioned effects may be a result of CDK inhibitor p21 up-regulation as well as MAPK and NF-kappaB inhibition. Hence, HDAC inhibitors appear to be an innovative strategy for RA management.
URI: http://scholarbank.nus.edu.sg/handle/10635/22126
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ChooQY.pdf3.78 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

307
checked on Dec 11, 2017

Download(s)

365
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.