Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/21605
Title: Oral Chemotherapy by Poly (Lactide) - Vitamin E TPGS/Montmorillonite Nanoparticles
Authors: ANITHA PANNEERSELVAN
Keywords: Anticancer drugs; Biodegradable polymers; Cancer nanotechnology; Drug delivery device; Oral Chemotherapy; Medical clay; Nanomedicine
Issue Date: 7-Aug-2009
Source: ANITHA PANNEERSELVAN (2009-08-07). Oral Chemotherapy by Poly (Lactide) - Vitamin E TPGS/Montmorillonite Nanoparticles. ScholarBank@NUS Repository.
Abstract: Oral chemotherapy is a challenge for cancer treatment since most anticancer drugs are not orally bioavailable due to the gastrointestinal drug barrier. Nanoparticles may provide an ideal solution. In this work, the poly(lactide)-vitamin E TPGS/montmorillonite nanoparticles (PLA-TPGS/MMT NPs) were developed for oral delivery of Docetaxel used as a model drug. The design was made to take advantages of TPGS for high emulsification effects and high drug encapsulation efficiency and high cellular adsorption. MMT of similar effects is a detoxifier which cures the side effects caused by the formulated drug. The drug-loaded NPs were prepared by a modified solvent extraction/evaporation method and then characterized for their TPGS and MMT content, size and particle distribution, surface charge and morphology, drug encapsulation efficiency, and in vitro drug release profile. Cellular uptake of the fluorescent NPs was investigated. Both of the cancer cell line experiment and the animal test showed that the drug formulated in the NPs could achieve better therapeutic effects than the pristine drug TaxotereB.. The oral bioavailability can be enhanced from 3.59% for TaxotereB. to 91.3% for the PLA-TPGS NP formulation.
URI: http://scholarbank.nus.edu.sg/handle/10635/21605
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