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https://doi.org/10.1016/j.ccr.2010.04.028
Title: | PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase | Authors: | Wang, Haihe Vardy, Leah A Tan, Cheng Peow Loo, Jia Min Guo, Ke Li, Jie Lim, Seng Gee Zhou, Jianbiao Chng, Wee Joo Ng, Siok Bian Li, Hui Xiang Zeng, Qi |
Keywords: | Science & Technology Life Sciences & Biomedicine Oncology Cell Biology PROTEIN-TYROSINE PHOSPHATASES MESSENGER-RNA COLORECTAL-CANCER ERYTHROID-DIFFERENTIATION LIVER METASTASIS EXPRESSION INVASION OVEREXPRESSION MIGRATION MOTILITY |
Issue Date: | 13-Jul-2010 | Publisher: | CELL PRESS | Citation: | Wang, Haihe, Vardy, Leah A, Tan, Cheng Peow, Loo, Jia Min, Guo, Ke, Li, Jie, Lim, Seng Gee, Zhou, Jianbiao, Chng, Wee Joo, Ng, Siok Bian, Li, Hui Xiang, Zeng, Qi (2010-07-13). PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase. CANCER CELL 18 (1) : 52-62. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ccr.2010.04.028 | Abstract: | Overexpression of phosphatase of regenerating liver (PRL)-3 is associated with the progression of diverse human cancers. We show that the overexpression of PRL-3 protein is not directly associated with its transcript levels, indicating the existence of an underlying posttranscriptional regulation. The 5' untranslanted region (UTR) of PRL-3 mRNA possesses triple GCCCAG motifs capable of suppressing mRNA translation through interaction with PolyC-RNA-binding protein 1 (PCBP1), which retards PRL-3 mRNA transcript incorporation into polyribosomes. Overexpression of PCBP1 inhibits PRL-3 expression and inactivates AKT, whereas knockdown of PCBP1 causes upregulation of PRL-3 protein levels, activation of AKT, and promotion of tumorigenesis. An inverse correlation between protein levels of PRL-3 and PCBP1 in human primary cancers supports the clinical relevance. © 2010 Elsevier Inc. | Source Title: | CANCER CELL | URI: | https://scholarbank.nus.edu.sg/handle/10635/206676 | ISSN: | 15356108 18783686 |
DOI: | 10.1016/j.ccr.2010.04.028 |
Appears in Collections: | Staff Publications Elements |
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PCBP1 suppresses PRL3 phosphatase Cancer cell 2010.pdf | Published version | 1.19 MB | Adobe PDF | CLOSED | None |
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