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https://doi.org/10.1093/cvr/cvz057
Title: | Toll-like receptor 7 deficiency promotes survival and reduces adverse left ventricular remodelling after myocardial infarction | Authors: | de Kleijn, Dominique PV Chong, Suet Yen Wang, Xiaoyuan Yatim, Siti Maryam JM Fairhurst, Anna-Marie Vernooij, Flora Zharkova, Olga Chan, Mark Y Foo, Roger SY Timmers, Leo Lam, Carolyn SP Wang, Jiong-Wei |
Keywords: | TLR7 Myocardial infarction Inflammation Fibrosis Left ventricular remodelling PREVENTS CARDIAC RUPTURE SYSTEMIC-LUPUS-ERYTHEMATOSUS CARDIOVASCULAR-DISEASE EXTRACELLULAR-MATRIX HEART MICE RNA INFLAMMATION MODEL DYSFUNCTION |
Issue Date: | 1-Oct-2019 | Publisher: | OXFORD UNIV PRESS | Citation: | de Kleijn, Dominique PV, Chong, Suet Yen, Wang, Xiaoyuan, Yatim, Siti Maryam JM, Fairhurst, Anna-Marie, Vernooij, Flora, Zharkova, Olga, Chan, Mark Y, Foo, Roger SY, Timmers, Leo, Lam, Carolyn SP, Wang, Jiong-Wei (2019-10-01). Toll-like receptor 7 deficiency promotes survival and reduces adverse left ventricular remodelling after myocardial infarction. CARDIOVASCULAR RESEARCH 115 (12) : 1791-1803. ScholarBank@NUS Repository. https://doi.org/10.1093/cvr/cvz057 | Abstract: | Aims: The Toll-like receptor 7 (TLR7) is an intracellular innate immune receptor activated by nucleic acids shed from dying cells leading to activation of the innate immune system. Since innate immune system activation is involved in the response to myocardial infarction (MI), this study aims to identify if TLR7 is involved in post-MI ischaemic injury and adverse remodelling after MI. Methods and results: TLR7 involvement in MI was investigated in human tissue from patients with ischaemic heart failure, as well as in a mouse model of permanent left anterior descending artery occlusion in C57BL/6J wild type and TLR7 deficient (TLR7-/-) mice. TLR7 expression was up-regulated in human and mouse ischaemic myocardium after MI. Compared to wild type mice, TLR7-/- mice had less acute cardiac rupture associated with blunted activation of matrix metalloproteinase 2, increased expression of tissue inhibitor of metalloproteinase 1, recruitment of more myofibroblasts, and the formation of a myocardial scar with higher collagen fibre density. Furthermore, inflammatory cell influx and inflammatory cytokine expression post-MI were reduced in the TLR7-/- heart. During a 28-day follow-up after MI, TLR7 deficiency resulted in less chronic adverse left ventricular remodelling and better cardiac function. Bone marrow (BM) transplantation experiments showed that TLR7 deficiency in BM-derived cells preserved cardiac function after MI. Conclusions: In acute MI, TLR7 mediates the response to acute cardiac injury and chronic remodelling probably via modulation of post-MI scar formation and BM-derived inflammatory infiltration of the myocardium. | Source Title: | CARDIOVASCULAR RESEARCH | URI: | https://scholarbank.nus.edu.sg/handle/10635/206178 | ISBN: | 17553245 | ISSN: | 00086363 | DOI: | 10.1093/cvr/cvz057 |
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Toll-like receptor 7 deficiency promotes survival and reduces adverse left ventricular remodelling after myocardial infarction.pdf | Published version | 2.08 MB | Adobe PDF | CLOSED | Published |
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