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https://doi.org/10.3389/fendo.2018.00682
Title: | Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women | Authors: | Dias, Thiran Siraj, Shahul Hameed Mohamed Aris, Izzuddin Mohamed Li, Ling-Jun Tan, Kok Hian |
Keywords: | gestational diabetes mellitus screening pregnancy IADSPG WHO 1999 |
Issue Date: | 15-Nov-2018 | Publisher: | FRONTIERS MEDIA SA | Citation: | Dias, Thiran, Siraj, Shahul Hameed Mohamed, Aris, Izzuddin Mohamed, Li, Ling-Jun, Tan, Kok Hian (2018-11-15). Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women. FRONTIERS IN ENDOCRINOLOGY 9. ScholarBank@NUS Repository. https://doi.org/10.3389/fendo.2018.00682 | Abstract: | Introduction: While the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria is widely adopted in many countries, clinicians have questioned the applicability of these diagnostic thresholds for different races/ethnicities. We first compared the prevalence of gestational diabetes mellitus (GDM) diagnosed with different criteria including IADPSG, World Health Organization (WHO) 1999 and Sri Lankan national guidelines, and subsequently related individual guidelines-specific GDM prevalence to offspring birthweight in Sri Lanka. Materials and Methods: We retrospectively collected data on singleton pregnancies (n = 795) from two tertiary hospitals in Sri Lanka. We applied three diagnostic guidelines to define GDM, namely IADPSG criteria, the Sri Lankan national and WHO 1999 guidelines. We calculated the age- and first booking BMI-adjusted prevalence rates of GDM and assessed the association of GDM (using each guideline) with birthweight. Results: The age- and first booking BMI-adjusted GDM prevalence rates were 31.2, 28.0, and 13.1% for IADPSG criteria, Sri Lankan national and WHO 1999 guidelines, respectively. The IADPSG criteria identified 90 distinctive GDM cases at a lower cut-off of fasting glucose (from 5.1 to 5.5 mmol/L) while Sri Lankan national guideline identified 15 distinctive GDM cases at a lower cut-off for 2-h glucose (from 7.8 to 8.4 mmol/L). After adjusting for age, GDM diagnosed by IADPSG criteria was associated with higher birthweight [90.8 g, 95% CI: 10.8, 170.9], while the associations for GDM diagnosed either by Sri Lankan national or WHO 1999 guidelines were not significant. Conclusion: Adopting the IADPSG criteria for diagnosing GDM may be important in Sri Lankan pregnant population. | Source Title: | FRONTIERS IN ENDOCRINOLOGY | URI: | https://scholarbank.nus.edu.sg/handle/10635/194722 | ISSN: | 16642392 | DOI: | 10.3389/fendo.2018.00682 |
Appears in Collections: | Staff Publications Elements |
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