Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/18825
Title: Advanced Control Strategies for Automatic Drug Delivery to Regulate Anesthesia during Surgery
Authors: YELNEEDI SREENIVAS
Keywords: Hypnosis, Analgesia, Bispectral Index, Model Predictive Control, Internal Model Control, PID Control
Issue Date: 12-Dec-2009
Source: YELNEEDI SREENIVAS (2009-12-12). Advanced Control Strategies for Automatic Drug Delivery to Regulate Anesthesia during Surgery. ScholarBank@NUS Repository.
Abstract: Monitoring and control of depth of general anesthesia is very important since over- and under-dosing can be dangerous for the well-being of the patient during surgery. In order to provide safe and adequate anesthesia, the anesthesiologist must guarantee hypnosis (unconsciousness) and analgesia (pain relief). Automation of anesthesia is very useful as it will provide more time and flexibility to anesthesiologists to focus on critical issues that may arise during the surgery. The objective of this doctoral work is to determine the best infusion rates of the anesthetic and analgesic drugs such that the patient?s anesthetic state is well regulated even as the side-effects (due to overdose) are minimized and guarantee a minimum amount of drug in the blood pool. First, several controllers (PI, PID, PID-P, PID-PI and RTDA (robustness, set-point tracking, disturbance rejection, aggressiveness)) were designed for regulation of hypnosis with the inhalational drug isoflurane, and their performances were compared with the performance of model predictive controller (MPC) for various disturbances, set-point changes and signal loss which can occur during the surgery. Later, performance of the designed MPC for regulation of hypnosis with isoflurane was compared with that of internal model controller (IMC) and controller with modeling error compensation (MEC) for several set-point changes and disturbances that occur during surgery. Then, they were extended to regulate hypnosis by infusing intravenous drug: propofol. Finally, MPC strategy was extended for simultaneous regulation of hypnosis and analgesia by infusing intravenous drugs, propofol and remifentanil, respectively.
URI: http://scholarbank.nus.edu.sg/handle/10635/18825
Appears in Collections:Ph.D Theses (Open)

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