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https://doi.org/10.4269/ajtmh.14-0628
Title: | Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore | Authors: | Yung, C.-F Lee, K.-S Thein, T.-L Tan, L.-K Gan, V.C Wong, J.G.X Lye, D.C Ng, L.-C Leo, Y.-S |
Keywords: | envelope protein nonstructural protein 1 virus protein virus RNA virus antibody abdominal pain adult aged arthralgia Article clinical feature dengue Dengue virus Dengue virus 1 Dengue virus 2 Dengue virus 3 Dengue virus 4 disease severity drowsiness female fever genotype hematocrit hematological parameters human infection risk leukocyte count major clinical study male mucosal bleeding outcome assessment prospective study protein blood level real time polymerase chain reaction reverse transcription polymerase chain reaction serotype Singapore species difference systolic blood pressure thrombocyte count world health organization adolescent blood classification cohort analysis dengue Dengue virus genetics immunology isolation and purification middle aged risk serotype serotyping Severe Dengue severity of illness index very elderly virology young adult Dengue virus Adolescent Adult Aged Aged, 80 and over Antibodies, Viral Cohort Studies Dengue Dengue Virus Female Genotype Humans Male Middle Aged Prospective Studies Risk RNA, Viral Serogroup Serotyping Severe Dengue Severity of Illness Index Singapore Species Specificity Young Adult |
Issue Date: | 2015 | Publisher: | American Society of Tropical Medicine and Hygiene | Citation: | Yung, C.-F, Lee, K.-S, Thein, T.-L, Tan, L.-K, Gan, V.C, Wong, J.G.X, Lye, D.C, Ng, L.-C, Leo, Y.-S (2015). Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore. American Journal of Tropical Medicine and Hygiene 92 (5) : 999-1005. ScholarBank@NUS Repository. https://doi.org/10.4269/ajtmh.14-0628 | Rights: | Attribution 4.0 International | Abstract: | Studies on serotype-specific features of dengue and disease severity on adults are limited. We prospectively recruited adult febrile patients without alternate diagnosis to dengue from April 2005 to December 2011. Outcomes were defined using both the World Health Organization (WHO) 1997 and 2009 criteria; Dengue hemorrhagic fever (DHF) and severe dengue (SD). Infecting serotype was identified in 469 dengue-confirmed patients comprising 22.0% dengue virus serotype 1 (DENV-1), 57.1% DENV-2, 17.1% DENV-3, and 3.8% DENV-4. Cases infected with DENV-1 were more likely to present with red eyes whereas presence of joint pain and lower platelet count was associated with DENV-2 cases. After adjusting for potential confounders, DENV-1 was associated with both DHF (adjusted Relative Risk [aRR] = 1.74) and SD (aRR = 2.1) whereas DENV-2 had a lower risk of DHF (aRR = 0.5). DENV-1 genotype 1 and DENV-2 cosmopolitan were the predominant genotypes identified. Infecting dengue serotype and possibly genotype may play an important role in disease severity among adult dengue patients in Singapore. Copyright © 2015 by The American Society of Tropical Medicine and Hygiene. | Source Title: | American Journal of Tropical Medicine and Hygiene | URI: | https://scholarbank.nus.edu.sg/handle/10635/183890 | ISSN: | 0002-9637 | DOI: | 10.4269/ajtmh.14-0628 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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