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https://doi.org/10.1002/brb3.897
Title: | Acupuncture in the treatment of fatigue in Parkinson's disease: A pilot, randomized, controlled, study | Authors: | Kong, K.H Ng, H.L Li, W Ng, D.W Tan, S.I Tay, K.Y Au, W.L Tan, L.C.S |
Keywords: | acupuncture adult aged Article clinical article controlled study daytime somnolence Epworth sleepiness scale fatigue Geriatric Depression Scale human mood motor performance Parkinson disease pilot study priority journal questionnaire randomized controlled trial Unified Parkinson Disease Rating Scale very elderly complication fatigue female male middle aged Parkinson disease treatment outcome Acupuncture Therapy Aged Fatigue Female Humans Male Middle Aged Parkinson Disease Pilot Projects Surveys and Questionnaires Treatment Outcome |
Issue Date: | 2018 | Publisher: | John Wiley and Sons Ltd | Citation: | Kong, K.H, Ng, H.L, Li, W, Ng, D.W, Tan, S.I, Tay, K.Y, Au, W.L, Tan, L.C.S (2018). Acupuncture in the treatment of fatigue in Parkinson's disease: A pilot, randomized, controlled, study. Brain and Behavior 8 (1) : e00897. ScholarBank@NUS Repository. https://doi.org/10.1002/brb3.897 | Rights: | Attribution 4.0 International | Abstract: | Introduction: Fatigue is a common and disabling problem in patients with Parkinson's disease (PD), and there is currently no satisfactory treatment. As acupuncture has been reported to be effective in fatigue related to other conditions, we sought to evaluate its efficacy in PD. Methods: This was a single center, randomized, sham-controlled study. Forty PD patients with moderately severe fatigue were randomized to receive 5 weeks of biweekly real or sham acupuncture. The primary outcome was change on the General Fatigue score of the Multidimensional Fatigue Inventory (MFI-GF) at 5 weeks. Secondary outcomes included MFI-Total score, Unified Parkinson's Disease Rating Scale Motor score (UPDRS Motor), Parkinson's Disease Questionnaire-39 (PDQ 39), Geriatrics Depression Scale (GDS), and Epworth Sleepiness Scale ESS). All outcome measures were evaluated at baseline, 5 and 9 weeks. Results: Both groups showed significant improvements in MFI-GF and MFI-Total scores at 5 and 9 weeks, but there were no significant between-group differences. There were no improvements from baseline for PDQ 39, GDS, and ESS. Although improvements were noted for the UPDRS Motor score in the real acupuncture group, no between-group difference could be demonstrated. Conclusions: Both real and sham acupuncture are equally effective in improving PD-related fatigue, and it is likely that this is due to nonspecific or placebo effects. © 2017 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. | Source Title: | Brain and Behavior | URI: | https://scholarbank.nus.edu.sg/handle/10635/183468 | ISSN: | 2162-3279 | DOI: | 10.1002/brb3.897 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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