Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/18341
Title: The BDSF-dependent cell-cell communication in Burkholderia Cenocepacia
Authors: DENG YINYUE
Keywords: BDSF; quorum sensing; virulence; signal interference
Issue Date: 19-Jan-2010
Source: DENG YINYUE (2010-01-19). The BDSF-dependent cell-cell communication in Burkholderia Cenocepacia. ScholarBank@NUS Repository.
Abstract: Previous study showed that AHL-type quorum sensing (QS) system is involved in the regulation of virulence and biofilm formation in Burkholderia cenocepacia. In this study, I focused on the identification and characterization of a novel QS signal, cis-2-dodecenoic acid (BDSF), from B. cenocepacia. Genetic analysis established that BDSF is associated with modulation of the bacterial virulence in conjunction with the AHL system. Furthermore, evidence is presented that BDSF plays a key role in interspecies and inter-kingdom cell-cell communication. Candida albicans germ tube formation was strongly inhibited by either co-culture with B. cenocepacia or by exogenous addition of physiological relevant level of BDSF. Similarly, addition of BDSF inhibited the QS systems and T3SS of Pseudomonas aeruginosa. In addition to B. cenocepacia, BDSF was found in all the other genomovars of the B. cepacia complex, suggesting that BDSF is a novel key QS signal in the B. cepacia complex.
URI: http://scholarbank.nus.edu.sg/handle/10635/18341
Appears in Collections:Ph.D Theses (Open)

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