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https://doi.org/10.7554/eLife.03180
Title: | CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection | Authors: | Linterman, M.A Denton, A.E Divekar, D.P Zvetkova, I Kane, L Ferreira, C Veldhoen, M Clare, S Dougan, G Espéli, M Smith, K.G.C |
Keywords: | CD134 antigen CD28 antigen cre recombinase forkhead transcription factor Foxp3 protein, mouse integrase ligand Tnfrsf4 protein, mouse animal cell differentiation cell proliferation cellular immunity Citrobacter rodentium cross presentation Enterobacteriaceae infection helper cell immunity immunology Influenza A virus metabolism microbiology mouse orthomyxovirus infection physiology signal transduction Animals Antigens, CD28 Cell Differentiation Cell Proliferation Citrobacter rodentium Cross-Priming Enterobacteriaceae Infections Forkhead Transcription Factors Immunity Immunity, Cellular Influenza A virus Integrases Ligands Mice Orthomyxoviridae Infections Receptors, OX40 Signal Transduction T-Lymphocytes, Helper-Inducer |
Issue Date: | 2014 | Citation: | Linterman, M.A, Denton, A.E, Divekar, D.P, Zvetkova, I, Kane, L, Ferreira, C, Veldhoen, M, Clare, S, Dougan, G, Espéli, M, Smith, K.G.C (2014). CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection. eLife 3 (41913) : Jan-21. ScholarBank@NUS Repository. https://doi.org/10.7554/eLife.03180 | Rights: | Attribution 4.0 International | Abstract: | The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in maintaining T cell responses following activation. To determine the role for CD28 after T cell priming, we generated a strain of mice where CD28 is removed from CD4+ T cells after priming. We show that continued CD28 expression is important for effector CD4+ T cells following infection; maintained CD28 is required for the expansion of T helper type 1 cells, and for the differentiation and maintenance of T follicular helper cells during viral infection. Persistent CD28 is also required for clearance of the bacterium Citrobacter rodentium from the gastrointestinal tract. Together, this study demonstrates that CD28 persistence is required for helper T cell polarization in response to infection, describing a novel function for CD28 that is distinct from its role in T cell priming. © Linterman et al. | Source Title: | eLife | URI: | https://scholarbank.nus.edu.sg/handle/10635/180376 | ISSN: | 2050084X | DOI: | 10.7554/eLife.03180 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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