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https://doi.org/10.1042/BSR20140021
Title: | Rho protein GTPases and their interactions with NF?B: Crossroads of inflammation and matrix biology | Authors: | Tong, L Tergaonkar, V |
Keywords: | cytokine guanosine nucleotide dissociation inhibitor I kappa B alpha immunoglobulin enhancer binding protein integrin protein Cdc42 protein p120 Rac protein Rac1 protein Rho factor Rho guanine nucleotide binding protein Rho guanine nucleotide exchange factor RhoA guanine nucleotide binding protein transcription factor RelA tumor necrosis factor alpha unclassified drug immunoglobulin enhancer binding protein protein Cdc42 Rac1 protein RAC1 protein, human RhoA guanine nucleotide binding protein RHOA protein, human article binding affinity cell adhesion extracellular matrix human immunoregulation inflammation molecular pathology nonhuman protein binding protein degradation protein domain protein expression protein function protein phosphorylation protein protein interaction protein transport signal transduction animal cell differentiation cell motion dermatitis extracellular matrix genetics inflammation metabolism pathology skin Animals cdc42 GTP-Binding Protein Cell Adhesion Cell Differentiation Cell Movement Dermatitis Extracellular Matrix Humans Inflammation NF-kappa B rac1 GTP-Binding Protein rhoA GTP-Binding Protein Skin |
Issue Date: | 2014 | Publisher: | Portland Press Ltd | Citation: | Tong, L, Tergaonkar, V (2014). Rho protein GTPases and their interactions with NF?B: Crossroads of inflammation and matrix biology. Bioscience Reports 34 (3) : 283-295. ScholarBank@NUS Repository. https://doi.org/10.1042/BSR20140021 | Rights: | Attribution 4.0 International | Abstract: | The RhoGTPases, with RhoA, Cdc42 and Rac being major members, are a group of key ubiquitous proteins present in all eukaryotic organisms that subserve such important functions as cell migration, adhesion and differentiation. The NF?B (nuclear factor ?B) is a family of constitutive and inducible transcription factors that through their diverse target genes, play a major role in processes such as cytokine expression, stress regulation, cell division and transformation. Research over the past decade has uncovered new molecular links between the RhoGTPases and the NF?B pathway, with the RhoGTPases playing a positive or negative regulatory role on NF?B activation depending on the context. The RhoA-NF?B interaction has been shown to be important in cytokine-activated NF?B processes, such as those induced by TNF? (tumour necrosis factor ?). On the other hand, Rac is important for activating the NF?B response downstream of integrin activation, such as after phagocytosis. Specific residues of Rac1 are important for triggering NF?B activation, and mutations do obliterate this response. Other upstream triggers of the RhoGTPase-NF?B interactions include the suppressive p120 catenin, with implications for skin inflammation. The networks described here are not only important areas for further research, but are also significant for discovery of targets for translational medicine. © 2014 The Author. | Source Title: | Bioscience Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/180179 | ISSN: | 0144-8463 | DOI: | 10.1042/BSR20140021 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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