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https://doi.org/10.1038/ncomms14334
Title: | Phylointeractomics reconstructs functional evolution of protein binding | Authors: | Kappei, D Scheibe, M Paszkowski-Rogacz, M Bluhm, A Gossmann, T.I Dietz, S Dejung, M Herlyn, H Buchholz, F Mann, M Butter, F |
Keywords: | protein shelterin telomere binding protein unclassified drug protein binding telomere binding protein enzyme activity evolution genomics marsupial molecular analysis phylogenetics protein proteomics Article human marsupial molecular evolution nonhuman phylogenomics phylointeractomics placental mammal protein binding protein function protein interaction proteomics telomere zebra fish animal biology cell culture conserved sequence DNA sequence genetics genome genomics metabolism molecular evolution phylogeny procedures proteomics sequence alignment vertebrate Danio rerio Eutheria Metatheria Vertebrata Animals Cells, Cultured Computational Biology Conserved Sequence Evolution, Molecular Genome Genomics Phylogeny Protein Binding Proteomics Sequence Alignment Sequence Analysis, DNA Telomere Telomere-Binding Proteins Vertebrates |
Issue Date: | 2017 | Publisher: | Nature Publishing Group | Citation: | Kappei, D, Scheibe, M, Paszkowski-Rogacz, M, Bluhm, A, Gossmann, T.I, Dietz, S, Dejung, M, Herlyn, H, Buchholz, F, Mann, M, Butter, F (2017). Phylointeractomics reconstructs functional evolution of protein binding. Nature Communications 8 : 14334. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms14334 | Rights: | Attribution 4.0 International | Abstract: | Molecular phylogenomics investigates evolutionary relationships based on genomic data. However, despite genomic sequence conservation, changes in protein interactions can occur relatively rapidly and may cause strong functional diversification. To investigate such functional evolution, we here combine phylogenomics with interaction proteomics. We develop this concept by investigating the molecular evolution of the shelterin complex, which protects telomeres, across 16 vertebrate species from zebrafish to humans covering 450 million years of evolution. Our phylointeractomics screen discovers previously unknown telomere-associated proteins and reveals how homologous proteins undergo functional evolution. For instance, we show that TERF1 evolved as a telomere-binding protein in the common stem lineage of marsupial and placental mammals. Phylointeractomics is a versatile and scalable approach to investigate evolutionary changes in protein function and thus can provide experimental evidence for phylogenomic relationships. © The Author(s) 2017. | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/179735 | ISSN: | 2041-1723 | DOI: | 10.1038/ncomms14334 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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