Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/17679
Title: Epigenetic potential of histone deacetylase inhibitors in treating fibroproliferative diseases and preventing peri-implantational fibrosis
Authors: WANG ZHIBO
Keywords: Histone deacetylase inhibitor, fibroproliferative disease, peri-implantational fibrosis, transforming growth factor β, fibroblast culture, collagen
Issue Date: 12-Aug-2009
Source: WANG ZHIBO (2009-08-12). Epigenetic potential of histone deacetylase inhibitors in treating fibroproliferative diseases and preventing peri-implantational fibrosis. ScholarBank@NUS Repository.
Abstract: Wound healing is an essential process for the repair of tissue damage after an injury. This process results in either the regeneration of parenchymal tissue or replacement with connective tissue (scars). Majority of damaged tissues in adults heal with scars. Normal scarring is well-regulated. However, pathological scarring, also called fibrosis, is out of control. Fibroproliferative diseases involve many organs of the body. The hallmark is the excessive deposition of collagen, which destroys the original structure and impairs its function as well. Peri-implantational fibrosis occurs after implantation. It represents the end stage of a foreign body reaction directed by the host to implants. Peri-implantational fibrosis, characterized by a collagenous capsule, compromises the performance of implants and causes implantation failure. To this day, there is neither effective treatment for fibroproliferative diseases nor effective prevention of peri-implantational fibrosis. To explore
URI: http://scholarbank.nus.edu.sg/handle/10635/17679
Appears in Collections:Ph.D Theses (Open)

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