Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/17537
Title: In vivo and in vitro study on potential combination therapy of COL-3 and tamoxifen in breast cancer: a pilot study
Authors: ZHENG LIN
Keywords: tamoxifen, COL-3, breast cancer, combination therapy, pharmacokinetics, anti-proliferative effect
Issue Date: 5-Feb-2007
Source: ZHENG LIN (2007-02-05). In vivo and in vitro study on potential combination therapy of COL-3 and tamoxifen in breast cancer: a pilot study. ScholarBank@NUS Repository.
Abstract: This thesis project is a preclinical study on the potential combination therapy of tamoxifen with COL-3, a matrix metalloproteinases inhibitor in breast cancer therapy. Pharmacokinetic (PK) study was performed on female rats to examine the pharmacokinetic profile of COL-3 alone, or in combination of low-dose/high-dose tamoxifen in fed/fasted rats. When fed rats were pretreated with high-dose tamoxifen before COL-3a??s oral administration, absorption of COL-3 was found extensively inhibited. In order to find evidence to support our hypothesis that food may play a role in this unexpected phenomenon in COL-3 PK profile, in vitro dissolution/diffusion study was carried out to mimic the physiological environment in gastrointestinal tract. Anti-proliferative effects of COL-3, when given alone and in the combination with tamoxifen, were evaluated in estrogen-receptor-positive (MCF-7) and estrogen-receptor-negative (MDA-MB-231) breast cancer cell lines. Four different PK models were proposed and compared to characterize the PK aspect of COL-3 under various conditions.
URI: http://scholarbank.nus.edu.sg/handle/10635/17537
Appears in Collections:Master's Theses (Open)

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