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https://doi.org/10.1161/JAHA.117.005586
Title: | Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction | Authors: | Drum C.L. Tan W.K.Y. Chan S.-P. Pakkiri L.S. Chong J.P.C. Liew O.-W. Ng T.-P. Ling L.-H. Sim D. Leong K.-T.G. Yeo D.P.S. Ong H.-Y. Jaufeerally F. Wong R.C.C. Chai P. Low A.F. Davidsson P. Liljeblad M. Söderling A.-S. Gan L.-M. Bhat R.V. Purnamawati K. Lam C.S.P. Richards A.M. |
Keywords: | amino terminal pro brain natriuretic peptide biological marker CD40 antigen CD40 ligand sex hormone thymosin beta4 troponin T actin binding protein biological marker thymosin thymosin beta(4) adult age aged all cause mortality Article clinical trial controlled study female heart failure with preserved ejection fraction heart failure with reduced ejection fraction heart infarction heart left ventricle ejection fraction human immunoassay liquid chromatography-mass spectrometry major clinical study male middle aged New York Heart Association class priority journal prognosis prognostic assessment prospective study protein blood level protein expression proximity extension assay sex sex difference X chromosome linkage blood comparative study disease exacerbation follow up heart failure heart stroke volume liquid chromatography mass spectrometry pathophysiology physiology sex factor Aged Biomarkers Chromatography, Liquid Disease Progression Female Follow-Up Studies Heart Failure Humans Male Mass Spectrometry Microfilament Proteins Middle Aged Prognosis Prospective Studies Sex Factors Stroke Volume Thymosin |
Issue Date: | 2017 | Citation: | Drum C.L., Tan W.K.Y., Chan S.-P., Pakkiri L.S., Chong J.P.C., Liew O.-W., Ng T.-P., Ling L.-H., Sim D., Leong K.-T.G., Yeo D.P.S., Ong H.-Y., Jaufeerally F., Wong R.C.C., Chai P., Low A.F., Davidsson P., Liljeblad M., Söderling A.-S., Gan L.-M., Bhat R.V., Purnamawati K., Lam C.S.P., Richards A.M. (2017). Thymosin beta-4 is elevated in women with heart failure with preserved ejection fraction. Journal of the American Heart Association 6 (6). ScholarBank@NUS Repository. https://doi.org/10.1161/JAHA.117.005586 | Abstract: | Background-Thymosin beta-4 (TB4) is an X-linked gene product with cardioprotective properties. Little is known about plasma concentration of TB4 in heart failure (HF), and its relationship with other cardiovascular biomarkers. We sought to evaluate circulating TB4 in HF patients with preserved (HFpEF) or reduced (HFrEF) ejection fraction compared to non-HF controls. Methods and Results-TB4 was measured using a liquid chromatography and mass spectrometry assay in age- and sexmatched HFpEF (n=219), HFrEF (n=219) patients, and controls (n=219) from a prospective nationwide study. Additionally, a 92-marker multiplex proximity extension assay was measured to identify biomarker covariates. Compared with controls, plasma TB4 was elevated in HFpEF (985 [421-1723] ng/mL versus 1401 [720-2379] ng/mL, P<0.001), but not in HFrEF (1106 [556-1955] ng/mL, P=0.642). Stratifying by sex, only women (1623 [1040-2625] ng/mL versus 942 [386-1891] ng/mL, P<0.001), but not men (1238.5 [586-1967] ng/mL versus 1004 [451-1538] ng/mL, P=1.0), had significantly elevated TB4 in the setting of HFpEF. Adjusted for New York Heart Association class, N-terminal pro B-type natriuretic peptide, age, and myocardial infarction, hazard ratio to all-cause mortality is significantly higher in women with elevated TB4 (1.668, P=0.036), but not in men (0.791, P=0.456) with HF. TB4 is strongly correlated with a cluster of 7 markers from the proximity extension assay panel, which are either X-linked, regulated by sex hormones, or involved with NF-?B signaling. Conclusions-We show that plasma TB4 is elevated in women with HFpEF and has prognostic information. Because TB4 can preserve EF in animal studies of cardiac injury, the relation of endogenous, circulating TB4 to X chromosome biology and differential outcomes in female heart disease warrants further study. © 2017 The Authors and AstraZeneca. | Source Title: | Journal of the American Heart Association | URI: | https://scholarbank.nus.edu.sg/handle/10635/175209 | ISSN: | 20479980 | DOI: | 10.1161/JAHA.117.005586 |
Appears in Collections: | Elements Staff Publications |
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