Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/17037
Title: Nanofibrous Surface Modification of Ultra-Thin PCL Membrane for Cardiovascular Tissue Engineering Application
Authors: CHEN FENGHAO
Keywords: PCL, cardiovascular tissue engineering, surface modification, nanofiber, electrospinning, cell attachment
Issue Date: 2-Nov-2006
Source: CHEN FENGHAO (2006-11-02). Nanofibrous Surface Modification of Ultra-Thin PCL Membrane for Cardiovascular Tissue Engineering Application. ScholarBank@NUS Repository.
Abstract: Poly (e-caprolactone) (PCL) is a popularly used biomaterial for various tissue engineering applications, but this setback of unfavorable cell affinity hinders its application for cardiovascular tissue engineering (CTVE) where a strong attachment between cells and scaffold is required. This thesis reports on a novel surface modification by extracellular matrix (ECM) mimic electrospun nanofibers. In this study, PCL membrane scaffold was coated with PCL nanofibers via electrospinning process and subjected to sodium hydroxide treatment The results revealed a uniform stable nanofibrous topology with increased roughness and surface area. Capillary effects were induced, causing almost zero water contact angle. Favorable cell proliferation, morphology and dramatically enhanced cell attachment were also observed on the hybrid scaffold.This study indicated that the nanofibrous surface modification remarkably enhanced the cell affinity to PCL membrane scaffold. We are optimistic that this technique has posed the way for future applications in CTVE.
URI: http://scholarbank.nus.edu.sg/handle/10635/17037
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