Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/17013
Title: Lactobacillus in cancer therapy
Authors: YONG JING YING
Keywords: Colon, cancer, lactobacilli, anti-proliferative, pro-apoptotic, interleukin-8
Issue Date: 18-Jul-2005
Source: YONG JING YING (2005-07-18). Lactobacillus in cancer therapy. ScholarBank@NUS Repository.
Abstract: Colon cancer is the second most common cancer in developed countries, as well as in Singapore. This study demonstrated that both Lactobacillus rhamnosus strain GG (LGG) and Lactobacillus casei strain Shirota (LcS) but not Lactobacillus bulgaricus (control bacteria) exerted specific dose dependent anti-proliferative effects on colon carcinoma cells. The results suggest that the anti-proliferative effects of LGG and LcS were due to their pro-apoptotic effects in colon carcinoma cells which were decreased in the presence of streptomycin. Experimental data indicated that nitric oxide production was not the cause of cytotoxicity. Cell-bacteria contact was also not necessary for the induction of anti-proliferative effects by lactobacilli, suggesting the presence of soluble cytotoxic mediators. There was absence of lactobacilli-induced interleukin-8 mRNA expression but increased protein secretion by colon carcinoma cells. This data indicates that commonly consumed lactobacilli can differentiated between normal and cancerous cells.
URI: http://scholarbank.nus.edu.sg/handle/10635/17013
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
01 Chap - Title page.pdf39.84 kBAdobe PDF

OPEN

NoneView/Download
02 Chap - Acknowledgements.pdf68 kBAdobe PDF

OPEN

NoneView/Download
03 Chap - Table of Contents.pdf86.41 kBAdobe PDF

OPEN

NoneView/Download
04 Chap - Summary.pdf67.8 kBAdobe PDF

OPEN

NoneView/Download
05 Chap - List of Figures.pdf69.7 kBAdobe PDF

OPEN

NoneView/Download
06 Chap - Abbreviations.pdf72.35 kBAdobe PDF

OPEN

NoneView/Download
07 Chap - Introduction.pdf2.33 MBAdobe PDF

OPEN

NoneView/Download
08 Chap - Materials and Methods.pdf180.64 kBAdobe PDF

OPEN

NoneView/Download
09 Chap - Results.pdf2.36 MBAdobe PDF

OPEN

NoneView/Download
10 Chap - Discussion.pdf152.94 kBAdobe PDF

OPEN

NoneView/Download
11 Chap - References.pdf168.98 kBAdobe PDF

OPEN

NoneView/Download
12 Chap - Bibliography.pdf62.45 kBAdobe PDF

OPEN

NoneView/Download
13 Chap - Appendix A.pdf66.02 kBAdobe PDF

OPEN

NoneView/Download
14 Chap - Appendix B.pdf71.35 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

698
checked on Dec 11, 2017

Download(s)

2,176
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.