Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16978
Title: Hippocampal nociceptive activation in the rat
Authors: TAI SIEW KIAN
Keywords: hippocampus field CA1, theta, synaptic excitability, formalin pain, signal-to-noise processing, behaving rat
Issue Date: 10-Nov-2005
Source: TAI SIEW KIAN (2005-11-10). Hippocampal nociceptive activation in the rat. ScholarBank@NUS Repository.
Abstract: In anaesthetized rat, hind paw injection of formalin, a model of persistent inflammatory pain, evoked a??signal-to-noisea?? processing marked by excitation of a select population of CA1 pyramidal cell against the background of widespread pyramidal cell suppression. These changes were observed in parallel with theta activation, theta being sinusoidal waveform that reflects rhythmic oscillation of CA1 neurons in processing of information. The aim of the present study was to investigate whether injection of formalin in behaving rat recruited the theta functional state of the hippocampus temporally linked to the animal nociceptive experience. Results showed that formalin induced biphasic theta activation that broadly paralleled the aversive behaviors. However, theta activation was not associated with any typical nociceptive behavior per se. Finally, synaptic excitability of CA1 pyramidal cells was attenuated following injection of formalin though the decrease was not biphasic suggesting varied mechanisms influencing theta activation and suppression of CA1 pyramidal cell excitability.
URI: http://scholarbank.nus.edu.sg/handle/10635/16978
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Thesis cover.pdf8.45 kBAdobe PDF

OPEN

NoneView/Download
Thesis spine.pdf8.01 kBAdobe PDF

OPEN

NoneView/Download
Thesis title.pdf9.01 kBAdobe PDF

OPEN

NoneView/Download
Thesis acknow contents summary.pdf34.54 kBAdobe PDF

OPEN

NoneView/Download
Thesis body.pdf1.3 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

206
checked on Dec 2, 2017

Download(s)

579
checked on Dec 2, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.