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https://doi.org/10.1002/anie.201906099
Title: | An AIEgen-Peptide Conjugate as a Phototheranostic Agent for Phagosome-Entrapped Bacteria | Authors: | Qi, Guobin Hu, Fang Kenry Shi, Leilei Wu, Min Liu, Bin |
Keywords: | Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry aggregation-induced emission antimicrobial agents fluorescence imaging infection photodynamic therapy FLUORESCENT-PROBES CASPASE-1 INFLAMMASOME RECOGNITION INFECTION ENZYME |
Issue Date: | 4-Nov-2019 | Publisher: | WILEY-V C H VERLAG GMBH | Citation: | Qi, Guobin, Hu, Fang, Kenry, Shi, Leilei, Wu, Min, Liu, Bin (2019-11-04). An AIEgen-Peptide Conjugate as a Phototheranostic Agent for Phagosome-Entrapped Bacteria. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58 (45) : 16229-16235. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201906099 | Abstract: | © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The detection and elimination of intracellular bacteria remain a major challenge. In this work, we report an aggregation-induced emission (AIE) bioprobe that can detect bacterial infection and kill bacteria surviving inside macrophages through a dynamic process, notably specific molecular tailoring of the probe by caspase-1 activation in infected macrophages and accumulation of the residue on phagosomes containing bacteria, leading to light-up fluorescent signals. Moreover, the AIEgen can serve as a photosensitizer for generation of reactive oxygen species (ROS); and the average ROS indicator fluorescent signal intensity per unit area in the bacterial phagosomes is approximately 2.7-fold higher than that in the cytoplasm. This, in turn, induces bacteria killing with high efficiency and minimal cytotoxicity towards macrophages. We envision that this specific light-up bioprobe may provide a new approach for selective and sensitive detection and eradication of intracellular bacterial infections. | Source Title: | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | URI: | https://scholarbank.nus.edu.sg/handle/10635/169703 | ISSN: | 14337851 15213773 |
DOI: | 10.1002/anie.201906099 |
Appears in Collections: | Staff Publications Elements |
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File | Description | Size | Format | Access Settings | Version | |
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Qi Guobin-Angew.pdf | Accepted version | 11.19 MB | Adobe PDF | OPEN | Post-print | View/Download |
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