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https://scholarbank.nus.edu.sg/handle/10635/16947
DC Field | Value | |
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dc.title | Neurite outgrowth inhibitors in axoglial communication at the node of ranvier | |
dc.contributor.author | NIE DUYU | |
dc.date.accessioned | 2010-05-13T19:25:23Z | |
dc.date.available | 2010-05-13T19:25:23Z | |
dc.date.issued | 2005-11-01 | |
dc.identifier.citation | NIE DUYU (2005-11-01). Neurite outgrowth inhibitors in axoglial communication at the node of ranvier. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/16947 | |
dc.description.abstract | How the organization of the nodes of Ranvier and abutting domains in myelinated axons is regulated by glial cells remains poorly understood. In this study, oligodendrocyte-myelin glycoprotein (OMgp) and Nogo-A are identified as clusters in the nodal and paranodal domains, respectively. In the CNS, OMgp is involved in a network of interactions with other nodal molecules, including Nav channel subunits and TN-R. In the transgenic mice, down-regulation of OMgp causes dis-organization of nodal structure and decreased expression of Nav channel I? subunit. In vitro, OMgp protein has no effects on Nav channel distribution and sodium currents. Paranodal Nogo-A interacts with Caspr/paranodin via the Nogo-66. In animal models such as the experimental autoimmune encephalomyelitis (EAE) rats, the ceramide galactosyltransferase (CGT) and myelin basic protein (MBP) deficient mice, disruption of Nogo-A-Caspr interaction leads to misplacement of Kv1 channels. The results have demonstrated that some a??inhibitorya?? glial molecules undertake specific roles in regulating axonal polarity. | |
dc.language.iso | en | |
dc.subject | node of Ranvier, axon-glia interaction, myelination, Nogo, oligodendrocyte-myelin glycoprotein (OMgp), TN-R | |
dc.type | Thesis | |
dc.contributor.department | ANATOMY | |
dc.contributor.supervisor | NG YEE KONG | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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Ph.D Thesis - NIE Duyu.pdf | 13.38 MB | Adobe PDF | OPEN | None | View/Download |
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