Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16934
Title: Characterization of gli2/2b genes in zebrafish hindbrain development
Authors: KE ZHIYUAN
Keywords: hindbrain, gli2, rhombomere, radial astrocyte, motoneuron, oligodendrocyte
Issue Date: 8-Nov-2006
Source: KE ZHIYUAN (2006-11-08). Characterization of gli2/2b genes in zebrafish hindbrain development. ScholarBank@NUS Repository.
Abstract: Gli are key mediators of Hedgehog signaling on regulating neurodevelopment in vertebrates. Previously, zebrafish Gli2 was characterized playing minor role in neurodevelopment, in contrast to the major role of mouse Gli2. In this study, second zebrafish gli2 (gli2b) was identified. Late regulation of gli2b expression depends on Hh and Notch signaling. Comparative analysis of the function of Gli2/Gli2b demonstrates their major roles as the Hedgehog-dependent activators for ventral neurodifferentiation, and the Hh-independent repressors for maintenance of dorsal neural progenitors. This study also demonstrates the joint activities of Gli2/Gli2b for several neural cell types and axonal guidance. Further, this study indicates that Gli2 dominant repressor of yot-/- doesnot interfere with all spectra of Gli2b functions, especially in rhomomere 4. In summary, this study helps to explain the functional differences of Gli2 between zebrafish and mice, and illustrate unknown developmental roles of Gli2 useful for the studies in other animals including human.
URI: http://scholarbank.nus.edu.sg/handle/10635/16934
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Kezy1.pdf910.24 kBAdobe PDF

OPEN

NoneView/Download
Kezy2.pdf901.93 kBAdobe PDF

OPEN

NoneView/Download
Kezy3.pdf1.26 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

185
checked on Dec 18, 2017

Download(s)

433
checked on Dec 18, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.