Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16751
Title: Crystal Structure Determination of KREMEN1, DICKKOPF1 and MeCP2
Authors: VINDHYA BANGALORE NARAYANA REDDY
Keywords: Wnt,Kremen,Dickkopf,Methyl,Cpg,crystal
Issue Date: 6-Jan-2009
Source: VINDHYA BANGALORE NARAYANA REDDY (2009-01-06). Crystal Structure Determination of KREMEN1, DICKKOPF1 and MeCP2. ScholarBank@NUS Repository.
Abstract: The canonical Wnt/beta catenin signaling pathway has been implicated in the development of skin appendages like hair follicle, teeth and mammary glands. Slight perturbations in this pathway lead to severe mammalian developmental defects in bone and eye formation, degenerative diseases and cancer. Kremen1 (Krm1), a transmembrane receptor, in association with the Dkk family protein Dickkopf1 (Dkk1), represses the pathway thereby regulating gastrulation events in Xenopus laevis. Therefore, we sought to investigate the mechanism of action of these antagonists by studying the crystal structure of the complex of Krm1 with Dkk1. DNA methylation has an essential regulatory function of repressing non-transcribed genes stably in differentiated adult somatic cells. MeCP2, a methyl CpG-binding protein, is one abundant mammalian protein which contributes to methylation dependent gene silencing. The determination of crystal structure of MeCP2 could aid us in understanding its protein transcription repression mechanism. Moreover, it could provide fundamental insights into the epigenetic modifications that affect mammalian development and normal cellular homeostasis.
URI: http://scholarbank.nus.edu.sg/handle/10635/16751
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
ReddyVBN.pdf1.88 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

232
checked on Dec 11, 2017

Download(s)

207
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.