Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16711
Title: Substance P regulates chemokine production in Leukocytes - implications in the pathogenesis of acute pancreatitis and associated lung injury
Authors: SUN JIA
Keywords: Acute pancreatitis, inflammatory mediators, neuropeptide, chemokines, leukocytes
Issue Date: 21-Feb-2009
Source: SUN JIA (2009-02-21). Substance P regulates chemokine production in Leukocytes - implications in the pathogenesis of acute pancreatitis and associated lung injury. ScholarBank@NUS Repository.
Abstract: The neuropeptide substance P (SP) is a well-recognized inflammatory mediator in acute pancreatitis. However, the mechanism remains elusive. The present study attempts to delineate the signal transduction cascade activated by SP in the regulation of release of inflammatory molecules that contribute to disease progression. It is found that SP modulates chemokine release from leukocytes, particularly neutrophils and macrophages, thereby contributing to the inflammatory responses during acute pancreatitis. In neutrophils, SP, acting via the neurokinin-1 receptor (NK-1R), induces NF-kappaB activation through the classical activation pathway leading to chemokine expression and secretion. Additionally, SP upregulates cell-surface chemokine receptor expression to promote neutrophil trafficking towards chemokines. In macrophages, SP induces a complex signal transduction cascade involving PKC isoforms, PI3K/Akt, MAP kinases ERK1/2 and transcription factor NF-kappaB resulting in chemokine production. This work contributes to current understanding on SP-related pathogenetic pathway in acute pancreatitis and highlights anti-inflammatory therapeutic targets for the condition.
URI: http://scholarbank.nus.edu.sg/handle/10635/16711
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Thesis cover and title page Sun Jia HT050847U.pdf22.04 kBAdobe PDF

OPEN

NoneView/Download
Final amended thesis Sun Jia HT050847U.pdf12.89 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

221
checked on Dec 11, 2017

Download(s)

243
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.