Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16617
Title: Development of new human stem cell - derived cellular vehicles for glioma gene therapy
Authors: ZHAO YING
Keywords: Stem cell, cellular vehicle, glioma, gene therapy
Issue Date: 12-Jan-2009
Source: ZHAO YING (2009-01-12). Development of new human stem cell - derived cellular vehicles for glioma gene therapy. ScholarBank@NUS Repository.
Abstract: Malignant glioma remains one of the most lethal forms of cancer in humans. However, current therapy for glioma rarely achieves long-term tumor control. Stem cell-based gene therapy is a promising new strategy for the treatment of glioma. Neural stem cells are highly efficacious in targeting brain tumors and show a specific affinity for invading glioma cells. Genetically engineered neural stem cells expressing therapeutic genes can inhibit the growth of glioma, facilitate elimination of tumor cells, and repair damaged brain tissue. As such, neural stem cells may be effective delivery vehicles for gene therapy to malignant neoplasms in the brain. However, the mechanism of glioma-tropic behavior in neural stem cells is not well understood. Furthermore, there are significant ethical issues limiting the use of stem cells of fetal origin. This study aimed to discover new regulators that might enhance cell migration toward gliomas and sought to develop alternative, large-scale sources of neural stem cells for use in gene therapy for glioma.
URI: http://scholarbank.nus.edu.sg/handle/10635/16617
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