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Title: Functions of cytoplasmic dynein in drosophila epithelia cells
Keywords: cytoplasmic dynein, drosophila, epithelial cell
Issue Date: 28-Feb-2009
Citation: LI ZHOUHUA (2009-02-28). Functions of cytoplasmic dynein in drosophila epithelia cells. ScholarBank@NUS Repository.
Abstract: The work studies the functions of cytoplasmic dynein in follicular cells (FCs). Two of its functions are addressed: cellular polarity and Notch (N) signaling. Dynein mutant FCs lose apical/basal polarity. Dynein primarily functions through the localization of Crumbs (Crb) complex. Dynein transports both Crb protein and transcripts to the apical domain, and the apically localized crb transcript is required for the full activity of Crb. Dynein also regulate the trafficking and activation of N. Notch signaling is blocked in dynein mutant FCs. N accumulates in the early/sorting endosomes in dynein mutant. Genetic and biochemical data suggest that S2 product of N is trapped in dynein mutant. Furthermore, dynein is likely recruited to the early/sorting endosomes via Rab11. Similar phenotype is also observed in Rab11 mutant. Taken together, these data suggest that there is an endocytic/recycling step between S2 and S3 cleavage of N.
Appears in Collections:Ph.D Theses (Open)

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