Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16574
Title: Intra-Cellular Endoplasmic Reticulum Dynamics, Distribution and function in response to cell-engineered surface adhesion
Authors: ZHANG XIN
Keywords: endoplasmic reticulum, cell adhesion, microtubule, kinectin, kinesin, focal complex
Issue Date: 8-Jan-2009
Source: ZHANG XIN (2009-01-08). Intra-Cellular Endoplasmic Reticulum Dynamics, Distribution and function in response to cell-engineered surface adhesion. ScholarBank@NUS Repository.
Abstract: In tissue engineering research, the regulation of cell behaviors in engineered extra-cellular environments is crucial for the development of seeded cells to desired tissues that can perform physiological functions. The current understanding of the cell behavior regulation is limited to factors that can induce cytoskeleton rearrangement and cellular deformations. In fact, the transportation, arrangement and functions of the intra-cellular components may also greatly influence cell phenotypes and functions. In this thesis, we found that endoplasmic reticulum (ER) tubules can extend into cellular lamella formed in cell membrane adhesion. The extension is microtubule and kinectin (ER membrane protein)-kinesin (motor protein) interaction dependent. Disruption of the kinectin-kinesin interaction can inhibit ER tubule dynamics and extension. ER tubules at cellular lamella can interact with focal complexes and is important for focal complex growth. As consequences of the inhibited ER tubule extension into cellular lamella, cell migration and spreading are significantly retarded.
URI: http://scholarbank.nus.edu.sg/handle/10635/16574
Appears in Collections:Ph.D Theses (Open)

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