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Title: Characterization and comparison of oncogene transgenic zebrafish in three different transgenic systems
Keywords: mMyc,Xmrk,zebrafish,liver cancer,tet-on, lfabp
Issue Date: 21-Aug-2009
Citation: LIANG BING (2009-08-21). Characterization and comparison of oncogene transgenic zebrafish in three different transgenic systems. ScholarBank@NUS Repository.
Abstract: Zebrafish is a small fresh water fish, which is beginning to be exploited as a model for human disease and biomedical research. Cancer can be experimentally induced in zebrafish by over expressing oncogenes in transgenic zebrafish lines., and the induction of clonally derived T cell acute lymphoblastic leukemia in transgenic zebrafish has been reported by expressing mouse c-myc (mMyc) under control of the zebrafish Rag2 promoter. Xmrk is a receptor tyrosine kinase closely related to the human EGF receptor, and it is first identified in the melanoma system of the fish Xiphophorus. In this study, three oncogene transgenic zebrafish lines were developed and characterized: two inducible expression lines with oncogene mMyc-Tg(lfabp:Tre/rtTA-mMyc-GFP) and Tg(mvtg1:mMyc-GFP), and one direct expression line with oncogene Xmrk-Tg (lfabp:Xmrk). The study of oncogene transgenic zebrafish can provide valuable insights into the mechanism of cancer development and also help in the screening of therapeutic molecules.
Appears in Collections:Master's Theses (Open)

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