Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16541
Title: Function studies on ring proteins in white spot syndrome virus
Authors: HE FANG
Keywords: WSSV,RING,Ubiquitination,TSL,anti-apoptosis,IE1 promoter
Issue Date: 25-Feb-2009
Source: HE FANG (2009-02-25). Function studies on ring proteins in white spot syndrome virus. ScholarBank@NUS Repository.
Abstract: White Spot Syndrome Virus, Nimaviridiae Whispovirus, is one of the major viral pathogens in the aquaculture industry responsible for high mortality in cultured shrimp. The infection mechanisms of WSSV have not been fully characterized at the molecular level due to the large size and uniqueness of its genome. This study was undertaken to advance our understanding of the specific function of RING-containing proteins in viral pathogenesis.A preliminary search for regulatory protein candidates in WSSV using functional domain determination identified four predicted viral proteins containing a RING-H2 domain. Among them, the three proteins WSSV222, WSSV249 and WSSV403 can be expressed in both E.coli and insect cells, suggesting their potential expression in shrimp. In this study, emphasis has been placed on the characterization of WSSV222 and WSSV403 for viral pathogenesis.
URI: http://scholarbank.nus.edu.sg/handle/10635/16541
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
phd He Fang09.pdf2.48 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

294
checked on Dec 11, 2017

Download(s)

306
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.