Please use this identifier to cite or link to this item:
Title: Myoblast fusion and muscle development in Drosophila melanogaster
Keywords: myoblast,muscle,drosophila,differentiation,fusion,heterochromatin
Issue Date: 28-Sep-2009
Citation: SARADA HARICHAND BULCHAND (2009-09-28). Myoblast fusion and muscle development in Drosophila melanogaster. ScholarBank@NUS Repository.
Abstract: Drosophila body wall muscles are multinucleate fibres formed in the embryonic mesoderm by specification, attraction and successive fusions between a founder myoblast and several fusion competent myoblasts. Their location, size, points of attachment and innervation are critical for their contractile function. <br>I addressed how founder specific extracellular signals, via the receptor Dumbfounded (Duf), are transduced intracellularly to downstream effectors. Studies were carried out using a Duf structure function analysis approach. I found that putative Duf signaling domains act additively and cooperatively to affect fusion.<br>To identify novel myogenic genes a mutagenesis screen was performed. I identified a mutation in a novel gene responsible for histone mRNA transcription and pre-mRNA processing. The mutant displayed a degenerating musculature and mis-processed histone transcripts. While early fusion events were not disrupted, late structural organization was defective and muscle specific transcripts were mis regulated. This might imply changes in heterochromatin by the action of mis regulated modified histone proteins.<br>
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
BulchandSH.pdf17.81 MBAdobe PDF



Page view(s)

checked on Nov 17, 2018


checked on Nov 17, 2018

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.