Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16530
Title: Myoblast fusion and muscle development in Drosophila melanogaster
Authors: SARADA HARICHAND BULCHAND
Keywords: myoblast,muscle,drosophila,differentiation,fusion,heterochromatin
Issue Date: 28-Sep-2009
Source: SARADA HARICHAND BULCHAND (2009-09-28). Myoblast fusion and muscle development in Drosophila melanogaster. ScholarBank@NUS Repository.
Abstract: Drosophila body wall muscles are multinucleate fibres formed in the embryonic mesoderm by specification, attraction and successive fusions between a founder myoblast and several fusion competent myoblasts. Their location, size, points of attachment and innervation are critical for their contractile function. <br>I addressed how founder specific extracellular signals, via the receptor Dumbfounded (Duf), are transduced intracellularly to downstream effectors. Studies were carried out using a Duf structure function analysis approach. I found that putative Duf signaling domains act additively and cooperatively to affect fusion.<br>To identify novel myogenic genes a mutagenesis screen was performed. I identified a mutation in a novel gene responsible for histone mRNA transcription and pre-mRNA processing. The mutant displayed a degenerating musculature and mis-processed histone transcripts. While early fusion events were not disrupted, late structural organization was defective and muscle specific transcripts were mis regulated. This might imply changes in heterochromatin by the action of mis regulated modified histone proteins.<br>
URI: http://scholarbank.nus.edu.sg/handle/10635/16530
Appears in Collections:Ph.D Theses (Open)

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