Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16528
Title: The role of p38 MAPK in cell cycle checkpoint control following DNA damage
Authors: PHONG SIEW PENG, MARK
Keywords: p38MAPK, DNA Damage, Cell Cycle, G2 Arrest
Issue Date: 2-Mar-2009
Source: PHONG SIEW PENG, MARK (2009-03-02). The role of p38 MAPK in cell cycle checkpoint control following DNA damage. ScholarBank@NUS Repository.
Abstract: The p38 MAPK is activated by DNA Damage, however its activity is not required for the activation and maintenace of the G2 cell cycle checkpoint arrest in transformed cancer cells. Instead p38 MAPK activity in response to DNA damage is similar to its role as a stress kinase. We observed that increased p38 pathway activity confers survival advantages to cancer cells through the regulation of the apoptosis pathways, specifically the anti-apoptotic BCL2 family proteins. This pathway may be exploited by cancer cells to evade apoptosis and hence increase survival.
URI: http://scholarbank.nus.edu.sg/handle/10635/16528
Appears in Collections:Ph.D Theses (Open)

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