Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16527
Title: MicroRNAs in fat cell development and obesity
Authors: XIE HUANGMING
Keywords: micrornas, adipogenesis, obesity, inflammation, brown fat, myogenesis
Issue Date: 30-Jun-2009
Source: XIE HUANGMING (2009-06-30). MicroRNAs in fat cell development and obesity. ScholarBank@NUS Repository.
Abstract: Obesity is a serious health problem worldwide associated with an increased risk of life-threatening diseases. A fundamental prerequisite for the development of novel therapeutics for obesity and its associated metabolic syndromes is an understanding of the regulation of fat cell development. Potential regulators include microRNAs, an abundant class of post-transcriptional regulators. In this study, we investigate the role of microRNAs in fat cell development and obesity with genome-wide expression profiling, characterization of specific microRNAs by gain-of-function approach and mechanistic study guided by computational analysis. Our results underlie the importance of microRNAs in adipose biology and have important therapeutic implications in the treatment of obesity.
URI: http://scholarbank.nus.edu.sg/handle/10635/16527
Appears in Collections:Ph.D Theses (Open)

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