Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16526
Title: Mechanical Models for Malaria Infected Erythtocytes
Authors: JIAO GUYUE
Keywords: Malaria, cell mechanics, finite element method, ABAQUS, micropipette aspiration, optical tweezers
Issue Date: 17-Aug-2009
Source: JIAO GUYUE (2009-08-17). Mechanical Models for Malaria Infected Erythtocytes. ScholarBank@NUS Repository.
Abstract: The erythrocytes play an important role in human body. The normal erythrocyte can undergo extremely large deformation while passing through small capillaries . When the erythrocyte is infected by a malaria Plasmodium falcipurum (P.f.), it loses its deformability. It is believed that the increase in stickiness and decrease in deformability of the malaria (P.f.) infected erythrocytes will lead to capillary blockage and obstruction of blood flow. In this thesis, a two-component model and a multi-component model were developed to investigate the decrease in deformability of malaria (P.f.) infected erythrocytes. Finite element analysis was done using ABAQUS to simulate the erythrocytes' deformation in micropipette aspiration and optical tweezers stretching. The comparison between simulation and experiments was able to quantitatively analyze the effect of shear modulus, bending stiffness and pasitophorous vacuole membrane (PVM) on the cells' deformation. These models can also study the validity of hemispherical cap model for micropipette aspiration.
URI: http://scholarbank.nus.edu.sg/handle/10635/16526
Appears in Collections:Ph.D Theses (Open)

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