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Title: Understanding Structure-Mechanical Property Relationship of Breast Cancer Cells
Keywords: Breast Cancer, Nucleus, Cell Mechanics, AFM, Micropipette Aspiration, Microfluidics
Issue Date: 13-Aug-2009
Citation: LI QINGSEN (2009-08-13). Understanding Structure-Mechanical Property Relationship of Breast Cancer Cells. ScholarBank@NUS Repository.
Abstract: Cancer has long been one of the leading causes of death in the world. Cell mechanics has been extended to study cancer from a mechanistic perspective in order to better understand the pathophysiology of cancer. In this thesis, mechanical properties of non-malignant (MCF-10A) and malignant breast epithelial cells (MCF-7) in suspension and adherent condition were characterized using different techniques including microfluidics, micropipette aspiration, AFM. MCF-7 was found to be twice softer than MCF-10A, and isolated nuclei of MCF-7 were also found to be twice softer than that of MCF-10A. Distinct difference was found both in the actin structure and nuclear structure of MCF-7 and MCF-10A. Our results indicate the structure-property relationship of breast cancer cells, which might help in cancer diagnosis and understanding mechanism of cancer metastasis.
Appears in Collections:Ph.D Theses (Open)

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