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Title: Targetting EBV associated malignancies using HLA-A2/EBNA-1 specific monoclonal antibodies
Keywords: EBV, EBNA-1, MHC, monoclonal antibody, T-cell receptor-like antibody
Issue Date: 2-Feb-2009
Citation: EIO YATING, MICHELLE (2009-02-02). Targetting EBV associated malignancies using HLA-A2/EBNA-1 specific monoclonal antibodies. ScholarBank@NUS Repository.
Abstract: MHC/peptide complexes provide a specific and unique target for immune-based therapeutic approaches. Hence an antibody that mimics the specificity of cytotoxic T lymphocytes and recognises MHC/peptide complexes on the surface of tumour cells, represents an attractive new targeting strategy. We have developed a T cell receptor-like antibody which targets EBV nuclear antigen 1 (EBNA-1) in the context of HLA-A201 using conventional hybridoma techniques with a high degree of specificity. In our study, we detail the generation and characterisation of this monoclonal antibody. We demonstrate that this antibody exhibits a specific binding pattern and binds with high affinity to HLA-A201/EBNA-1 complexes on the surface of EBV transformed B-lymphoblastoid cell lines, tumour cell lines and NPC biopsies. In addition, this antibody is able to detect constitutive levels of HLA-A201/EBNA-1 complexes and as such represents a novel reagent for EBV research and for targeting EBV-associated malignant cells.
Appears in Collections:Master's Theses (Open)

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