Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16372
Title: Transglutaminase in human corneal epithelial cells
Authors: TONG HAK TIEN, LOUIS
Keywords: Transglutaminase, inflammation, ocular surface, cornea, epithelium, ophthalmology
Issue Date: 18-Aug-2009
Source: TONG HAK TIEN, LOUIS (2009-08-18). Transglutaminase in human corneal epithelial cells. ScholarBank@NUS Repository.
Abstract: Inflammatory cellular signaling underlies diseases of the surface of the eye such as keratoconjunctivitis sicca, pterygium, allergic conjunctivitis as well as scarring from infections. Conventional treatments for inflammation have relied principally on glucocorticoids which are well known to produce adverse events such as glaucoma and cataract. To develop more specific therapies, the origins and consequences of inflammatory signaling must be understood for ocular surface cells. One gene group ,the transglutaminases (TGM), has emerged as a class of enzymes that cross-link cellular substrates to mediate critical immune-inflammatory signaling. The studies in this thesis have established that TGM pathways are critical to the modulation of cell stress, and that TGM-related signaling pathways may contain useful therapeutic targets to combat ocular surface diseases.
URI: http://scholarbank.nus.edu.sg/handle/10635/16372
Appears in Collections:Ph.D Theses (Open)

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