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Title: Hydrogen sulfide, a cardioprotective agent in ischemic heart
Keywords: Hydrogen sulfide, Cardioprotection, Ischemia, Ischemic preconditioning, Myocardial infarction, Protein Kinase C
Issue Date: 4-Jul-2009
Citation: PAN TINGTING (2009-07-04). Hydrogen sulfide, a cardioprotective agent in ischemic heart. ScholarBank@NUS Repository.
Abstract: Ischemic heart disease is a global health problem. In the current study, the role of H2S in the cardioprotection against ischemia injury was investigated in both in vivo and in vitro models. In an isolated cardiomyocyte model, inhibition of endogenous H2S blocked the early and late cardioprotection induced by ischemic preconditioning. Preconditioning myocytes with a H2S donor, NaHS, protected cells against ischemia-caused cell death, injury and impairment on cell function. Such protection was mediated through opening of sarcolemmal KATP channels, release of NO and activation of PKC. In an in vivo rat model, a single bolus of NaHS protected the heart from myocardial infarction for at least 3 days. These findings demonstrated that for the population with high risk of ischemic heart disease, H2S preconditioning may represent an effective approach to protect the heart.
Appears in Collections:Ph.D Theses (Open)

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