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Title: Immune markers and protective mechanisms in latent and active tuberculosis
Keywords: tuberculosis, LTBI, mycobacterium inhibition
Issue Date: 26-Jun-2009
Citation: KANG SU LIN, JOANNE (2009-06-26). Immune markers and protective mechanisms in latent and active tuberculosis. ScholarBank@NUS Repository.
Abstract: To identify immune correlates of protection in tuberculosis (TB), cytokine mRNA profiles, regulatory factors, specific responses to mycobacterium antigens and in vitro mycobactericidal activity were analysed, building an immune profile of TB patients, healthy TB contacts with latent tuberculosis infection (LTBI) and uninfected individuals. Tuberculin reactivity and peripheral blood mononuclear cell responses to purified protein derivative, correlated with mycobactericidal activity only in uninfected persons, who had better mycobacterium-inhibition than LTBI subjects. In TB patients, strong reactivity to Mycobacterium tuberculosis-specific antigens was associated with lower protective and higher T regulatory cytokine activity, and poorer mycobactericidal activity. LTBI groups showed a balance of pro- and anti-inflammatory cytokines. A novel mycobacterium-inhibition assay developed identified individuals with balanced profile of pro-inflammatory and regulatory cytokines to be more protected than those with mainly either pro- or anti-inflammatory cytokines. This study identified biomarker profiles characterising those with protective mycobactericidal activity, in clinically healthy and TB patients.
Appears in Collections:Ph.D Theses (Open)

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