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Title: FRMD4A regulates the entry of West Nile virus into glioblastoma cells
Keywords: West Nile Virus, Ferm Domain, Glioblastoma cells, Differential Permissivity, alphaV Beta3 integrin
Issue Date: 28-Aug-2009
Citation: PANG JUNXIONG, VINCENT (2009-08-28). FRMD4A regulates the entry of West Nile virus into glioblastoma cells. ScholarBank@NUS Repository.
Abstract: FRMD4A was proposed to be an antiviral host factor that can resist WNV infection, found only in A172 cells in this study. Based on indirect immunofluorescence confocal microscopy, FRMD4A was observed to interact with the activated alphaV beta3 integrin via the FERM domain at the Nterminal of FRMD4A protein. Activated alphaV beta3 integrin have been shown previously to mediate WNV entry via the activated focal adhesion kinase (FAK) pathway. Through bioinformatics analyses, it was observed that FERM domain of FRMD4A may compete with FAK binding event to the activated alphaV beta3 integrin. As a result, the level of phosphorylation of FAK was affected that might have hindered the entry of WNV. Hence, this study provided insights into how FRMD4A regulates the entry of WNV via the activated alphaV beta3 integrin pathway in A172 cells, making them less permissive to WNV infection. The entry event is often a major determinant of virus tropism and pathogenesis (Schneider-Schaulies, 2000). Understanding this early event of virus infection in more details will provide opportunities to develop strategies to reduce the burden of WNV infection.
Appears in Collections:Master's Theses (Open)

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