Please use this identifier to cite or link to this item:
Title: Understanding phosphatidylinositol 3-kinase independent survival pathways in the prostate cancer model, LNCaP
Keywords: prostate cancer, Bcl-xL, androgen signaling, apoptosis, cell survival
Issue Date: 27-Apr-2007
Citation: TEONG HUEY FERN (2007-04-27). Understanding phosphatidylinositol 3-kinase independent survival pathways in the prostate cancer model, LNCaP. ScholarBank@NUS Repository.
Abstract: Constitutive activation of the PI3-K/Akt pathway is known to be the major survival pathway in LNCaP, a prostate cancer model which has a frameshift mutation in the PTEN gene resulting in a defective PTEN. Recent studies have shown that PI3-K/Akt independent survival pathway existed in LNCaP as apoptosis triggered by PI3-K inhibitors in serum-free condition can be blocked by the addition of growth factors such as serum, EGF and androgen. In this study, we show that the PI3-K/Akt independent survival pathway in LNCaP mediated by androgen requires the activity of androgen receptor (AR) and it is probably due to the up-regulation of the anti-apoptotic protein Bcl-xL through STAT3 activation. The increase in Bcl-xL induced by androgen could block apoptosis caused by inhibition of PI3-K probably by binding to pro-apoptotic counterpart Bak to oppose its killing activity. Thus STAT3 and Bcl-xL expression are critical for the androgen-mediated PI3-K independent cell survival.
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Teong Huey Fern-MSc-Biochemistry-2007.pdf4.17 MBAdobe PDF



Page view(s)

checked on Feb 3, 2019


checked on Feb 3, 2019

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.