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Title: Electrospun Nanofibre Scaffolds for Tissue Engineered Small-Diameter Vascular Grafts
Authors: HE WEI
Keywords: electrospinning, nanofibers, tissue engineering, vascular grafts. scaffolds
Issue Date: 25-Sep-2008
Citation: HE WEI (2008-09-25). Electrospun Nanofibre Scaffolds for Tissue Engineered Small-Diameter Vascular Grafts. ScholarBank@NUS Repository.
Abstract: The scope of this research encompasses construction of tissue engineered small-diameter vascular grafts by hybridizing electrospun nanofiber scaffolds with endothelial cells (ECs). The nanofiber scaffolds, which contain synthetic poly(L-lactic acid)-co-poly(N5-caprolactone) P(LLA-CL) and natural collagen type I, displayed features of ECM-like architectures, high porosity, bioactive surface, suitable mechanical properties, and controllable fiber alignment. In vitro human coronary artery endothelial cells culture onto the scaffolds shows that (1) nanofiber meshes supported effective endothelialization in terms of viability, attachment, as well as phenotypic and functional maintenance of ECs; (2) 3-D blood vessel-like tubular nanofiber scaffolds facilitated quick and stable endothelialization in the lumen of the scaffolds using a customized seeding technique. In vivo implantation of the tubular P(LLA-CL) nanofiber scaffolds into a rabbit model to replace the inferior superficial epigastric vein showed a patency of the scaffolds for 7 weeks, which proved the basic concept of using the tubular nanofiber scaffolds as vascular grafts.
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