Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/16066
Title: The role of adenosine, adenosine receptors and transporters in the modulation of cell death
Authors: SUN WENTIAN
Keywords: Adenosine, adenosine receptor, apoptosis, nucleoside transporter
Issue Date: 14-Oct-2008
Source: SUN WENTIAN (2008-10-14). The role of adenosine, adenosine receptors and transporters in the modulation of cell death. ScholarBank@NUS Repository.
Abstract: In this research, the apoptotic effects of adenosine and the mechanisms were studied. Adenosine-induced apoptosis was characterized by both early and late apoptosis criteria and observed to be cell type-dependent. Agonists and antagonists studies suggested GPCRs mediate apoptosis at low adenosine concentrations while nucleoside transporters at high adenosine concentrations. Key players/events of the apoptosis were identified, including the hyperpolarization and depolarization of mitochondria, translocation of Bax and cytochrome c, elevation of cytosolic Ca2+ level, cellular acidification and activation of caspases. Intrinsic apoptosis was suggested with mitochondria being at the centre of the apoptosis pathway. An integrated extra-intracellular mechanism for adenosine-induced apoptosis was proposed. In this model, two apoptotic signaling pathways respond to adenosine at low and high extracellular adenosine concentrations. This model also provides an explanation for the multifaceted character of adenosine-induced apoptosis across a wide range of adenosine concentrations and cell types.
URI: http://scholarbank.nus.edu.sg/handle/10635/16066
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