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Title: Action of diclofenac and meloxicam on nephrotoxic cell death
Authors: NG LIN ENG
Keywords: diclofenac, meloxicam, cell death, mitochondria, MDCKII, LLC-PK1
Issue Date: 23-Jun-2008
Citation: NG LIN ENG (2008-06-23). Action of diclofenac and meloxicam on nephrotoxic cell death. ScholarBank@NUS Repository.
Abstract: The present study aimed to investigate the difference in toxicity of meloxicam and diclofenac using isolated kidney mitochondria and cultured MDCK and LLC-PK1 renal cells. Both drugs were shown to cause mitochondrial dysfunction by uncoupling oxidative phosphorylation resulting in a decrease in the biosynthesis of ATP and mitochondrial membrane potential. Diclofenac was demonstrated to inhibit the malate-aspartate shuttle. Experiments using cultured kidney cells revealed that diclofenac was more toxic than meloxicam as cell viability was compromised at a lower drug concentration. Measurement of caspase activities and cytochrome c release alluded to cell-death by apoptosis in meloxicam-treated cells while necrosis seemed to play a role in diclofenac-treated cells. In conclusion, though both drugs have direct effect on mitochondrial function, meloxicam was less potent than diclofenac in causing renal cell death and the different mode of cell death suggested that diclofenac-treated cells were more severely injured compared to meloxicam-treated cells.
Appears in Collections:Master's Theses (Open)

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