Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15990
Title: Identification and characterization of the candida albicans iron ferroxidase genes reveals novel partnerships with iron permeases for high-affinity iron uptake
Authors: TANG CHIH WEI, JASON
Keywords: iron; ferroxidase; high-affinity iron uptake
Issue Date: 5-Jun-2008
Source: TANG CHIH WEI, JASON (2008-06-05). Identification and characterization of the candida albicans iron ferroxidase genes reveals novel partnerships with iron permeases for high-affinity iron uptake. ScholarBank@NUS Repository.
Abstract: High-affinity iron transporters in fungi are two-component systems consisting of a specific pair of multicopper ferroxidase and iron permease. An organism may contain two such transporters, one localizing to the plasma membrane for iron uptake and the other at the vacuolar membrane for vacuole-cytosol iron transport. The pathogenic fungus Candida albicans possesses five multicopper ferroxidases and three iron permeases. Here, we have investigated the regulation and functions of the ferroxidase genes and their partnerships with the permeases. FET3, FET34 and FET99 were observed to be the only ferroxidases that exhibited elevated transcription in low-iron conditions. Co-localisation studies suggested Ftr1p/Fet34p and Fth1p/Fet3p partnerships. Interestingly, Fet99p appeared to be able to partner Ftr1p in the absence of Fet34p. This was supported by the loss of iron-uptake only upon deletion of FET34 and FET99. This alternate partnership for the high-affinity iron uptake might be beneficial for C. albicans survival and virulence.
URI: http://scholarbank.nus.edu.sg/handle/10635/15990
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
TangCWJ-Title page.pdf4.05 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-Acknowledgements.pdf5.95 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-Table of Contents.pdf11.65 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-List of Figures.pdf12.24 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-List of Tables.pdf3.57 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-Abbreviations.pdf4.29 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-Summary.pdf12 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-Introduction.pdf171.05 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-Materials and Methods.pdf82.38 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-Results.pdf14.18 MBAdobe PDF

OPEN

NoneView/Download
TangCWJ-Discussion.pdf49.59 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-References.pdf122.08 kBAdobe PDF

OPEN

NoneView/Download
TangCWJ-Publication.pdf481.6 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

341
checked on Dec 18, 2017

Download(s)

1,709
checked on Dec 18, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.