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Title: PE-PGRS proteins in mycobacterial pathogenicity and host response
Authors: KOH KAH WEE
Keywords: tuberculosis, vaccine, host-pathogen interaction, antigen processing, PE-PGRS proteins, cellular immune response
Issue Date: 17-Apr-2009
Citation: KOH KAH WEE (2009-04-17). PE-PGRS proteins in mycobacterial pathogenicity and host response. ScholarBank@NUS Repository.
Abstract: The functions of the unique PE-PGRS protein family in mycobacteria are largely unknown. The proteins have a conserved N-terminal Pro-Glu (PE) domain and C-terminal polymorphic GC-rich repetitive sequences (PGRS). We investigated immune responses directed against two such proteins and their roles in host-pathogen interactions. The stability of PE-PGRS proteins against degradation was also studied. Active or latent tuberculosis patients showed strong antibody responses to Rv3812PE-PGRS, but not to Rv0978cPE-PGRS. The PGRS domain protected the highly unstable Rv0978cPE from proteolytic degradation, influencing antigen processing for CD8+ T cell recognition. Rv3812PE-PGRS protein was identified as a surface protein without involvement in mycobacterium cell entry. Cellular immune responses to the PGRS but not the PE domain were observed in mycobacterium-infected mice. Murine immunisation with Rv3812PE-PGRS induced B and T cell responses to both domains. The roles elucidated for PE-PGRS proteins in host-pathogen interactions are relevant to immunodiagnosis and immunoprophylaxis of early tuberculosis infection.
Appears in Collections:Ph.D Theses (Open)

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