Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15879
Title: Regulation of the Branch point between the glyoxylate shunt and the TCA cycle in mycobacteria
Authors: CHRISTINA VERENA MUELLER
Keywords: TCA cycle glyoxylate shunt isocitrate dehydrogenase
Issue Date: 4-Jun-2009
Source: CHRISTINA VERENA MUELLER (2009-06-04). Regulation of the Branch point between the glyoxylate shunt and the TCA cycle in mycobacteria. ScholarBank@NUS Repository.
Abstract: The aim of this Master project was to gain insight in the regulation of the branch point between the glyoxylate shunt and the TCA cycle in BCG. In contrast to E. coli, where this regulation has been well studied, little is known in M. tuberculosis. Since E. coli has only one ICL and one ICD, but M. tuberculosis does have two of each, the branch point might be differently regulated. So far, it has been predicted that in M. tuberculosis the branch point is regulated by phosphorylation of ICD-1 by the putative ICD kinase/phosphatase. Based on our experimental findings, we predict that ICD-2 is the only active ICD enzyme in BCG. Inactivity of ICD-1 requires a constantly operating glyoxylate shunt in order to permit growth of the BCG icd-2 knockout mutant. Overall, we suggest that ICD-1 and ICD-2 differ in their function and possibly in their form of regulation by the putative ICD kinase/phosphatase.
URI: http://scholarbank.nus.edu.sg/handle/10635/15879
Appears in Collections:Master's Theses (Open)

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