Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/15869
Title: KIR and TLR frequencies in Nasopharyngeal Carcinoma
Authors: PANG SHYUE WEI
Keywords: Nasopharyngeal carcinoma; killer cell immunoglobulin-like receptor; toll-like receptor
Issue Date: 4-Jun-2009
Source: PANG SHYUE WEI (2009-06-04). KIR and TLR frequencies in Nasopharyngeal Carcinoma. ScholarBank@NUS Repository.
Abstract: Nasopharyngeal carcinoma (NPC) is an EBV-associated malignancy, with known HLA associations. In this study, we examined KIR genotypes and TLR2, TLR4, TLR7, TLR8 and TLR9 SNPs in a case-control study of Singaporean Chinese to identify possible links between innate immunity and NPC. Our results suggested KIR3DL1 was protective in NPC and this was compounded when its HLA-Bw4 ligand was absent, implying that inhibitory KIR3DL1, in the absence of its ligands, is unable to inhibit NK cells, triggering increased cytolysis of EBV-infected cells, lowering NPC risk. A trend of increasing risk with increasing number of activating KIRs was also observed. Thus activating KIRs could activate NK cells, and trigger non-specific inflammatory responses, which predispose an individual to NPC. No significant associations were discovered between TLR2, TLR4, TLR7, TLR8 and TLR9 exonic SNPs and NPC. A total of nine informative SNPs were identified in TLR2, TLR8 and TLR9 and these SNPs were synonymous SNPs.
URI: http://scholarbank.nus.edu.sg/handle/10635/15869
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
PangSW.pdf9.7 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

340
checked on Dec 11, 2017

Download(s)

234
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.