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Title: Genetic control of vertebrate muscle cell identity
Keywords: Vertebrate Muscle Development Myogenesis Blimp1 Slow-twitch
Issue Date: 28-Apr-2009
Citation: LIEW HOE PENG (2009-04-28). Genetic control of vertebrate muscle cell identity. ScholarBank@NUS Repository.
Abstract: The skeletal muscles of vertebrates are typically composed of slow and fast-twitch fibres that differ in morphology, gene expression profiles, contraction speeds, metabolic properties and patterns of innervation. Slow-twitch muscle fibres are capable of repetitive low peak force contractions and are highly resistant to fatigue. In contrast, fast-twitch muscle fibres produce high peak force contractions for short durations before they become fatigued. During myogenesis, how muscle precursors are induced to mature into distinct slow or fast-twitch fibre types is inadequately understood. In this thesis, I investigated how the activity of the zinc finger and SET domain containing transcriptional regulator Blimp1 is required to specify slow muscle fate in zebrafish embryos. I found that Blimp1 activity is required for the expression of slow muscle differentiation genes, including the newly identified slow muscle specific myosin light chain and troponin C, as well as directly repressing genes require for fast muscle differentiation.
Appears in Collections:Ph.D Theses (Open)

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